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Evolving Nature’s Medicines in the Laboratory
A synthetic biology platform to discover, diversify, and evolve complex natural molecules, both small molecules and macromolecules, for safer and more effective therapies, including antibiotics and vaccines.
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Credit: Celine Wang
Natural glycoside biosynthesis
Biosynthesis of terpene-based glycosides in engineered microbes
Glycodiversification of natural products
Directed evolution of glycosyl-transferases towards diversification
with non-native sugars and sugar sequences
Automated glycan synthesis
An automated platform for the enzymatic synthesis of designer glycan sequences as a general tool for glycobiology research
Combining synthetic biology, metabolic engineering, as well as synthetic and analytical chemistry
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