Evolving Nature’s Medicines in the Laboratory
A synthetic biology platform to discover, diversify, and evolve complex natural molecules, both small molecules and macromolecules, for safer and more effective therapies, including antibiotics and vaccines.
Discovery & Biosynthesis of Complex Natural Products
Mining, reconstructing, and engineering biosynthetic pathways to access structurally complex natural molecules in microbial hosts.
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Molecular Diversification & Laboratory Evolution
Engineering and evolving enzymes and pathways to generate new-to-nature molecules with improved activity, selectivity, and stability.
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Next-Generation Therapeutics & Vaccines
Microbial and cell-based platforms for producing and optimizing glycosylated drugs, antibiotics, adjuvants, and vaccine antigens.
Combining synthetic biology, metabolic engineering, as well as synthetic and analytical chemistry
Natural glycoside biosynthesis
Biosynthesis of terpene-based glycosides in engineered microbes
Glycodiversification of natural products
Directed evolution of glycosyl-transferases towards diversification
with non-native sugars and sugar sequences
Automated glycan synthesis
An automated platform for the enzymatic synthesis of designer glycan sequences as a general tool for glycobiology research